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GLP-1 weekly injection

Wegovy®

semaglutide · Weekly injection (pen)

The weekly semaglutide pen, approved for chronic weight management and to reduce the risk of major cardiovascular events in adults with heart disease and excess weight.

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Drug classGLP-1 receptor agonist
Filled throughLicensed U.S. partner pharmacy
Starting dose0.25 mg once weekly
Available strengths
0.25 mg0.5 mg1 mg1.7 mg2.4 mg7.2 mg (Wegovy HD)

How it works

Semaglutide mimics GLP-1, a hormone that slows stomach emptying and signals fullness to the brain. The dose rises gradually over about four months to limit side effects.

How dosing works

Increase every 4 weeks to 2.4 mg maintenance. Wegovy HD 7.2 mg is an approved higher maintenance dose for eligible adults. Your clinician sets the pace based on how you feel and adjusts it through your portal.

Who shouldn't take it

  • Personal or family history of medullary thyroid carcinoma (MTC)
  • Multiple endocrine neoplasia syndrome type 2 (MEN 2)
  • Serious hypersensitivity to semaglutide

Your intake screens for these before a clinician reviews your chart.

Important safety information

Boxed warningRisk of thyroid C-cell tumors. Tell your clinician about any lump or swelling in your neck, trouble swallowing, hoarseness or shortness of breath.

Do not use if you have

  • Personal or family history of medullary thyroid carcinoma (MTC)
  • Multiple endocrine neoplasia syndrome type 2 (MEN 2)
  • Serious hypersensitivity to semaglutide

Serious risks

  • Pancreatitis: stop and get care for severe stomach pain that won't go away
  • Gallbladder problems, including gallstones
  • Low blood sugar, especially with insulin or a sulfonylurea
  • Kidney problems from dehydration after vomiting or diarrhea
  • Serious allergic reactions
  • Changes in vision in people with type 2 diabetes
  • Depression or thoughts of suicide: tell your clinician about mood changes
  • Risk of breathing food or liquid into the lungs during anesthesia or sedation

Common side effects

  • Nausea, vomiting, diarrhea or constipation
  • Stomach pain, indigestion or bloating
  • Fatigue, headache or dizziness
  • Injection-site reactions (injectables)

Pregnancy

Tell your clinician if you are pregnant, planning to become pregnant or breastfeeding. Weight-loss medicines are not used during pregnancy.

This is not the full safety information. Read the full prescribing information and talk with your clinician.

Other injections

All treatments

Not sure which is right for you?

Your clinician will recommend a medication based on your history, preferences and budget.

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Important safety information