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Rx · prescription required
Non-GLP-1 extended-release tablet

Contrave®

naltrexone-bupropion · Extended-release tablet

A non-GLP-1 option that works on the brain's hunger and reward pathways. It may suit people who can't take or tolerate GLP-1 medicines.

Confirmed at visit
Cash price varies by pharmacy. Your clinician confirms the manufacturer program at your visit. No membership or visit fees. Full refund if you aren't approved.
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Drug classOpioid antagonist and aminoketone antidepressant
Filled throughRetail or mail-order pharmacy
Starting dose1 tablet each morning for week 1
Available strengths
8 mg / 90 mg tablet

How it works

Naltrexone and bupropion act together on the brain's appetite and craving centers. The dose builds over four weeks.

How dosing works

Increase weekly to 2 tablets twice daily by week 4, following the label. Your clinician sets the pace based on how you feel and adjusts it through your portal.

Who shouldn't take it

  • Uncontrolled high blood pressure
  • Seizure disorder or history of seizures
  • Chronic opioid use
  • Current or past eating disorder
  • Use of an MAOI within 14 days

Your intake screens for these before a clinician reviews your chart.

Important safety information

Boxed warningSuicidal thoughts and behaviors. Antidepressants can increase suicidal thoughts in some people, especially those under 25. Watch for new or worsening mood changes and get help right away.

Do not use if you have

  • Uncontrolled high blood pressure
  • Seizure disorder or history of seizures
  • Chronic opioid use
  • Current or past eating disorder
  • Use of an MAOI within 14 days

Serious risks

  • Seizures: the risk rises with higher doses
  • Increased blood pressure and heart rate
  • Liver injury
  • Serious allergic reactions
  • Angle-closure glaucoma

Common side effects

  • Nausea, constipation or vomiting
  • Headache or dizziness
  • Trouble sleeping
  • Dry mouth

Pregnancy

Tell your clinician if you are pregnant, planning to become pregnant or breastfeeding. Weight-loss medicines are not used during pregnancy.

This is not the full safety information. Read the full prescribing information and talk with your clinician.

Other pills

All treatments

Not sure which is right for you?

Your clinician will recommend a medication based on your history, preferences and budget.

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Important safety information