Getting started · 6 min read
Pill or injection? Choosing a format with your clinician
Daily tablets are now an FDA-approved option. How Foundayo and the Wegovy pill differ, and when an injection still makes sense.
Until recently, the most effective weight-care medicines were all injections. That changed with two FDA-approved daily pills: the Wegovy pill (oral semaglutide) and Foundayo (orforglipron).
The two pills
Wegovy pill. The same medicine as the Wegovy pen, in tablet form. In the OASIS 4 trial, people taking the 25 mg tablet lost 16.6% of their weight on average when they took it as directed.1 It has a strict routine: take it on an empty stomach with a small sip of water, then wait 30 minutes before eating, drinking or taking other oral medicines.2
Foundayo. A small-molecule GLP-1 medicine, not a peptide, so it doesn't need the same fasting routine. In the ATTAIN-1 trial, the highest dose led to 12.4% average weight loss at 72 weeks.3 The FDA approved it in April 2026, and self-pay pricing through LillyDirect starts at $149 a month for the lowest dose.4
When an injection may still fit better
- You want the most weight loss seen in trials so far, which was with weekly tirzepatide.
- You'd rather handle treatment once a week than every morning.
- You take several morning medicines that would clash with the Wegovy pill's routine.
When a pill may fit better
- You'd prefer not to use needles.
- You travel often and don't want to keep pens refrigerated.
- You want a lower starting price.
Both formats carry the same boxed warning about thyroid C-cell tumors, and the same stomach-related side effects are common. Your clinician will help you choose based on your history and routine.
